研究方向
医学为导向的化学生物学研究：
人类糖组学解码新技术；
糖靶向疾病诊治新策略；
针对异常糖基化的体外诊断新试剂研发；
Research Interest
Our research interest spans chemistry, biology, materials science and medical sciences, with a main focus on the following three aspects.
Development of fluorescent and chemiluminescent chemical probes for glycotransferases, glycosidases and carbohydrate binding proteins.
Targeted disease diagnosis, therapy and theranostics using biocompatible materials functionalized with glycoclusters and/or other biomolecules including antibodies, peptides, aptamers and small-molecule ligands.
Development of diagnostic agents for disease biomarkers with abnormal glycosylation levels.
课题组简介
贺晓鹏（博士），华东理工大学，化学与分子工程学院，费林加诺贝尔奖科学家联合研究中心（田禾院士团队），教授，博士生导师，化学生物学专业博士点负责人；海军军医大学国家肝癌科学中心青年科技英才（王红阳院士团队兼职引进），国家自然科学基金委优秀青年科学基金获得者，上海市青年科技启明星。2011年博士毕业于华东理工大学，博士期间赴法国Cachan高等师范学校联合培养，毕业后留校从事博士后研究工作（合作导师：陈凯先院士）。
研究方向聚焦糖组学解码新技术与糖靶向疾病诊治新策略，迄今共发表SCI论文240余篇，其中以（共同）通讯/第一作者发表的代表性论文包括2篇Chem (Cell Press)，1篇PNAS，10篇J. Am. Chem. Soc.，3篇Angew. Chem. Int. Ed.，1篇Nat. Commun.，2篇Sci. Bull.，3篇Adv. Mater.，4篇Adv. Funct. Mater.，14篇Chem. Sci., 1篇Chem. Rev., 12篇Chem. Soc. Rev.，所有论文获引用15000次（H因子57），ESI高被引/热点论文20篇，申请国家发明专利10余项（其中8项获授权）。
2021年入选英国皇家化学会会士，2020–2025年连续6年入选爱思唯尔中国高被引学者，入选美国斯坦福大学和爱思唯尔数据库联合发布的“World’s Top 2% Scientists”（Single year 2022, 2025），曾获Thieme Chemistry Journals Award（2020），中国化学会青年化学奖（2018），中国化学会化学生物学突出贡献奖（35周岁以下）（2018）。作为项目负责人承担国家自然科学基金委“生物大分子动态修饰与化学干预”重大研究计划重点支持项目（2019–2022），并作为学术骨干进一步获集成项目资助（2023–2025；项目负责人：李佳研究员）。
招生专业
博士第一招生专业：化学生物学
博士第二招生专业：应用化学
工程博士招生专业：生物与医药
硕士第一招生专业：化学生物学
硕士第二招生专业：应用化学
工程硕士招生专业：生物与医药
Selected publications
[43] Imaging of Lipid Droplets in Living Cells and Mice with Metabolic Dysfunction-Associated Steatotic Liver Disease via a Galactose-Modified Supramolecular Near-Infrared Fluorescent Glycoprobe.
H.-M. Wang, L. Dong, Q.-L. Hao, L.-L. Sun, X.-R. Li, Y.-W. Yuan, M.-Y. Tang, J. Gong*, Y. Zang*, J. Li*, T. D. James*, X.-P. He*, H.-H. Han*
Adv. Funct. Mater. 2026, 36, e25887.
[42] Decoding the function of the human glycome using chemical glycoprobes and glycosensor arrays.
X.-P. He*
Chem. Soc. Rev. 2026, 55, 605-618. (2025 Pioneering Investigators)
[41] Twisted intramolecular charge transfer (TICT) based fluorescent probes and imaging agents.
Y. Wu, H.-M. Wang, X.-L. Hu, Y. Zang, J. Li*, H.-H. Han*, X.-P. He*, S. E. Lewis*, H. M. Ismail* , T. D. James*
Chem. Soc. Rev. 2025, 54, 12080-12141.
[40] Superresolution imaging of antibiotic-induced structural disruption of bacteria enabled by photochromic glycomicelles.
X.-L. Hu†, H.-Q. Gan†, W.-Z. Gui†, K.-C. Yan, J. L. Sessler*, D. Yi*, H. Tian, X.-P. He*
PNAS 2024, 121, e2408716121.
[39] Fluorogenic Peptide Sensor Array Derived from Angiotensin-Converting Enzyme Classifies Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern.
W.-T. Dou†, P.-H. Tong†, M. Xing†, J.-J. Liu, X.-L. Hu, T. D. James*, D.-M. Zhou*, X.-P. He*
J. Am. Chem. Soc. 2024, 146, 21017–21024.
[38] Theranostic Fluorescent Probes.
A. Sharma*, P. Verwilst, M.-L. Li, D.-D. Ma, N. Singh, J. Yoo, Y. Kim, Y. Yang, J.-H. Zhu, H.-Q. Huang, X.-L. Hu, X.-P. He*, L.-T. Zeng*, T. D. James*, X.-J. Peng*, J. L. Sessler*, J. S. Kim*
Chem. Rev. 2024, 124, 2699–2804. (ESI highly cited paper)
[37] Orthogonally Engineered Albumin with Attenuated Macrophage Phagocytosis for the Targeted Visualization and Phototherapy of Liver Cancer.
W.-T. Dou, P. Qiu, Y.-Y. Shi, L. Zhu, C. Guo, N. Li, Y. Zang, T.-T. Liu, S.-W. Zhao, Y.-F. Pan, L.-W. Dong, J. L. Sessler*, Y.-X. Tan*, J. Li*, H.-Y. Wang*, H. Tian, X.-P. He*
J. Am. Chem. Soc. 2023, 145, 17377–17388.
[36] Phenotyping of Methicillin-Resistant Staphylococcus aureus Using a Ratiometric Sensor Array.
X.-L. Hu†, H.-Q. Gan†, Z.-Y. Qin, Q. Liu, M. Li*, D.-J. Chen*, J. L. Sessler*, H. Tian, X.-P. He*
J. Am. Chem. Soc. 2023, 145, 8917-8926.
[35] The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy.
H.-H. Han, H.-M. Wang, P. Jangili, M. Li, L. Wu*, Y. Zang, A. C. Sedgwick*, J. Li*, X.-P. He*, T. D. James*, J. S. Kim*
Chem. Soc. Rev. 2023, 52, 879-920.(ESI highly cited paper)
[34] Fluorescent probes for the detection of chemical warfare agents.
W.-Q. Meng†*, A. C. Sedgwick†, N.Kwon, M. Sun, K. Xiao*, X.-P. He*, E. V. Anslyn*, T. D. James*, J. Yoon*
Chem. Soc. Rev. 2023, 52, 601-662.
[33] A homogeneous high-throughput array for the detection and discrimination of influenza A viruses.
W.-T. Dou†, X. Wang†, T. Liu, S. Zhao, J. Liu, Y. Yan, J. Li, C. Zhang, A. C. Sedgwick, H. Tian, J. L. Sessler*, D. M. Zhou*, X.-P. He*
Chem (Cell Press) 2022, 8, 1750-1761.
[32] Tuning the Solid- and Solution-State Fluorescence of the Iron-Chelator Deferasirox.
X.-L. Hu†, A. C. Sedgwick†*, D. N. Mangel†, Y. Shang, A. Steinbrueck, K. Yan, L. Zhu, D. W. Snelson, S. Sen, C. V. Chau, G. Juarez, V. M. Lynch, X.-P. He*, J. L. Sessler*
J. Am. Chem. Soc. 2022, 144, 7382–7390.
[31] Fluorescent probes for the detection of disease-associated biomarkers.
W.-T. Dou†, H.-H. Han†, A. C. Sedgwick, G.-B. Zhu, Y. Zang, X.-R. Yang*, J. Yoon*, T. D. James*, J. Li*, X.-P. He*
Sci. Bull. 2022, 67, 853-878. (ESI highly cited paper)
[30] Deferasirox (ExJade): An FDA-Approved AIEgen Platform with Unique Photophysical Properties.
A. C. Sedgwick†, K.-C. Yan†, D. N. Mangel†, Y. Shang, A. Steinbrueck, H.-H. Han, J. T. Brewster II, X.-L. Hu, D. W. Snelson, V. M. Lynch, H. Tian, X.-P. He*, J. L. Sessler*
J. Am. Chem. Soc. 2021, 143, 1278-1283. (ESI highly cited paper)
[29] Small-molecule fluorescence-based probes for interrogating major organ diseases.
H.-H. Han, H. Tian Jr., Y. Zang, A. C. Sedgwick, J. Li*, J. L. Sessler*, X.-P. He*, T. D. James*
Chem. Soc. Rev. 2021, 50, 9391-9429. (ESI highly cited paper)
[28] Photochromic Fluorescent Probe Strategy for the Super-resolution Imaging of Biologically Important Biomarkers.
X. Chai†, H.-H. Han†, A. C. Sedgwick†, N. Li, Y. Zang, T. D. James, J. Zhang*, X.-L. Hu, Y. Yu, Y. Li, Y. Wang, J. Li*, X.-P. He*, H. Tian
J. Am. Chem. Soc. 2020, 142, 18005-18013.
[27] Cyclodextrin-Based Peptide Self-Assemblies (Spds) That Enhance Peptide-Based Fluorescence Imaging and Antimicrobial Efficacy.
J.-B. Jiao†, G.-Z. Wang†, X.-L. Hu†, Y. Zang, S. Maisonneuve, A. C. Sedgwick, J. L. Sessler*, J. Xie*, J. Li*, X.-P. He*, H. Tian
J. Am. Chem. Soc. 2020, 142, 1925-1932.
[26] A Supramolecular‐Based Dual‐Wavelength Phototherapeutic Agent with Broad Spectrum Antimicrobial Activity against Drug Resistant Bacteria.
Z.-H. Yu†, X. Li†, F. Xu†, X.-L. Hu, J. Yan, N. Kwon, G.-R. Chen, T. Tang, X. Dong, Y. Mai*, D. Chen*, J. Yoon*, X.-P. He*, H. Tian
Angew. Chem. Int. Ed. 2020, 59, 3658-3664.
[25] Bio-Conjugated Advanced Materials for Targeted Disease Theranostics.
X.-L. Hu, N. Kwon, K.-C. Yan, A. C. Sedgwick, G.-R. Chen, X.-P. He*, T. D. James*, J. Yoon*
Adv. Funct. Mater. 2020, 30, 1907906.
[24] Förster Resonance Energy Transfer (FRET)-Based Small-Molecule Sensors and Imaging Agents.
L. Wu, C. Huang*, B. P. Emery, A. C. Sedgwick, S. D. Bull, X.-P. He, H. Tian*, J. Yoon*, J. L. Sessler*, T. D. James*
Chem. Soc. Rev. 2020, 49, 5110-5139. (ESI highly cited paper; ESI hot paper)
[23] Transition Metal Chelators, Pro-Chelators, and Ionophores as Small Molecule Cancer Chemotherapeutic Agents.
A. Steinbrueck, A. C. Sedgwick, J. T. Brewster II, K.-C. Yan, Y. Shang, D. M. Knoll, G. I. Vargas-Zúñiga, X.-P. He*, H. Tian*, J. L. Sessler*
Chem. Soc. Rev. 2020, 49, 3726-3747.
[22] Metal-Based Imaging Agents: Progress towards Interrogating Neurodegenerative Disease.
A. C. Sedgwick, J. T. Brewster II, P. Harvey*, D. A. Iovan, G. Smith, X.-P. He*, H. Tian*, J. L. Sessler*, T. D. James*
Chem. Soc. Rev. 2020, 49, 2886-2915.
[21] Fluorescent Glycoconjugates and Their Applications.
B. Thomas†, K.-C. Yan†, X.-L. Hu, M. Donnier-Maréchal, G.-R. Chen*, X.-P. He*, S. Vidal*
Chem. Soc. Rev. 2020, 49, 593-641.
[20] Multivalent Glycosheets for Double Light–Driven Therapy of Multidrug-Resistant Bacteria on Wounds.
X.-L. Hu, L.-Y. Chu, X.-J. Dong, G.-R. Chen, T.-T. Tang, D.-J. Chen*, X.-P. He*, He Tian
Adv. Funct. Mater. 2019, 29, 1806986.
[19] Self-assembled sialyllactosyl probes with aggregation-enhanced properties for ratiometric detection and blocking of influenza viruses.
W.-T. Dou, Z.-Y. Qin, J. Li, D.-M. Zhou, X.-P. He*
Sci. Bull. 2019, 64, 1902-1909.
[18] Fluorogenic Probes for Disease-Relevant Enzymes.
J. Zhang†, X. Chai†, X.-P. He*, H.-J. Kim*, J. Yoon*, H. Tian
Chem. Soc. Rev. 2019, 48, 683-722. (ESI highly cited paper)
[17] Lightening up Membrane Receptors with Fluorescent Molecular Probes and Supramolecular Materials.
X.-P. He, H. Tian*
Chem (Cell Press) 2018, 4, 246-268. (ESI highly cited paper)
[16] An ESIPT Probe for the Ratiometric Imaging of Peroxynitrite Facilitated by Binding to Aβ-Aggregates.
A. C. Sedgwick†, W.-T. Dou†, J.-B. Jiao, L. Wu, G. T. Williams, A. T. A. Jenkins, S. D. Bull, J. L. Sessler*, X.-P. He*, T. D. James*
J. Am. Chem. Soc. 2018, 140, 14267-14271.
[15] Photo-Controlled Fluorescence “Double-Check” Bioimaging Enabled by a Glycoprobe-protein Hybrid.
Y. Fu†, H.-H. Han†, J. Zhang*, X.-P. He*, B. L. Feringa, H. Tian*
J. Am. Chem. Soc. 2018, 140, 8671-8674.
[14] Supramolecular Nanostructures of Structurally Defined Graphene Nanoribbons in Aqueous Phase.
Y. Huang, W.-T. Dou, F. Xu, H.-B. Ru, Q. Gong, D. Wu, D. Yan, H. Tian, X.-P. He*, Y. Mai*, X. Feng
Angew. Chem. Int. Ed. 2018, 57, 3366-3371. (Very Important Paper)
[13] Excited-State Intramolecular Proton-Transfer (ESIPT) Based Fluorescence Sensors and Imaging Agents.
A. C. Sedgwick, L. Wu, H.-H. Han, S. D. Bull*, X.-P. He*, T. D. James*, J. L. Sessler*, B.- Z. Tang*, H. Tian*, J. Yoon*
Chem. Soc. Rev. 2018, 47, 8842-8880. (ESI highly cited paper; ESI hot paper)
[12] Remote Light-Controlled Intracellular Target Recognition by Photochromic Fluorescent Glycoprobes.
J. Zhang, Y. Fu, H.-H. Han, Y. Zang, J. Li*, X.-P. He*, B. L. Feringa, H. Tian*
Nat. Commun. 2017, 8, 987. (ESI highly cited paper; ESI hot paper; Highlighted by Sci. China Chem.)
[11] Fluorogenic 2D Peptidosheet Unravels CD47 as a Potential Biomarker for Profiling Hepatocellular Carcinoma and Cholangiocarcinoma Tissues.
Y.-H. Ma†, W.-T. Dou†, Y.-F. Pan, L.-W. Dong, Y.-X. Tan, X.-P. He*, H. Tian, H.-Y. Wang*
Adv. Mater. 2017, 29, 1604253. (ESI highly cited paper; Inside back cover)
[10] Multiplexed Photoluminescent Sensors: Towards Improved Disease Diagnostics.
Chem. Soc. Rev. 2017, 46, 6687-6696. (Tutorial review)
[9] Targeted Intracellular Production of Reactive Oxygen Species by a 2D Molybdenum Disulfide Glycosheet.
D.-K. Ji, Y. Zhang, Y. Zang, J. Li*, G.-R. Chen, X.-P. He*, H. Tian
Adv. Mater. 2016, 28, 9356-9363. (ESI hot paper)
[8] Rapid Identification of the Receptor-Binding Specificity of Influenza A Viruses by Fluorogenic Glycofoldamers.
X.-P. He*, Y.-L. Zeng, X.-Y. Tang, N. Li, D.-M. Zhou*, G.-R. Chen, H. Tian*
Angew. Chem. Int. Ed. 2016, 55, 13995-13999. (ESI hot paper; Inside back cover)
[7] Simultaneous Detection of Diverse Glycoligand-Receptor Recognitions Using a Single-Excitation, Dual-Emission Graphene Composite.
D.-K. Ji, G.-.R Chen, X.-P. He*, H. Tian
Adv. Funct. Mater. 2015, 25, 3483-3487.
[6] Probing Disease-Related Proteins with Fluorogenic Composite Materials.
Chem. Soc. Rev. 2015, 44, 4239-4248. (ESI highly cited paper; Tutorial review)
[5] Fluorogenic Probing of Specific Recognitions between Sugar Ligands and Glycoprotein Receptors on Cancer Cells by an Economic Graphene Nanocomposite.
H.-L. Zhang, X.-L. Wei, Y. Zang, J.-Y. Cao, S. Liu, X.-P. He*, Q. Chen, Y.-T. Long, J. Li*, G.-R. Chen*, K. Chen
Adv. Mater. 2013, 25, 4097-4101. (Front cover)
[4] Epimeric Monosaccharide-Quinone Hybrids on Gold Electrodes toward the Electrochemical Probing of Specific Carbohydrate–Protein Recognitions.
X.-P. He, X.-W. Wang, X.-P. Jin, H. Zhou, X.-X. Shi, G.-R. Chen, Y.-T. Long*
J. Am. Chem. Soc. 2011, 133, 3649-3657.
[3] Dual-Channel Fluorescent Probe for the Simultaneous Monitoring of Peroxynitrite and Adenosine-5′-triphosphate in Cellular Applications.
L. Wu, J Liu, X. Tian, R. R. Groleau, B. Feng, F. Yang, A. C. Sedgwick, H.-H. Han*, Y. Wang, H.-M. Wang, F. Huang, S. D. Bull, H. Zhang*, C. Huang*, Y. Zang, J. Li, X.-P. He, P. Li*, B. Tang, T. D. James*, J. L. Sessler*
J. Am. Chem. Soc. 2022, 144, 174–183. (ESI highly cited paper)
[2] Manganese (II) texaphyrin: a paramagnetic photoacoustic contrast agent activated by near-IR light.
Y. Ren, A. C. Sedgwick, J. Chen, G. Thiabaud, C. V. Chau, J. An, J. F. Arambula, X.-P. He, J. S. Kim*, J. L. Sessler*, C. Liu*
J. Am. Chem. Soc. 2020, 142, 16156-16160.
[1] Highly Enantioselective Construction of 3-Hydroxy Oxindoles through a Decarboxylative Aldol Addition of Trifluoromethyl α-Fluorinated gem-Diols to N-Benzyl Isatins.
I. Saidalimu, X. Fang, X.-P. He, J. Liang, X. Yang, F. Wu
Angew. Chem. Int. Ed. 2013, 52, 5566.
Books & Chapters
Fluorescent Chemosensors.
RSC 2023, ISBN: 978-1-83916-386-9
Chapter 4: Super-resolution Fluorescence Imaging.
RSC 2024, vol. 24, ch. 4, pp. 71-103.
Cover Gallery
